@article{oai:aue.repo.nii.ac.jp:00004692,
 author = {竹倉, 宏明 and 春日, 規克 and 吉岡, 利忠},
 issue = {1},
 journal = {体力科學},
 month = {Feb},
 note = {text, The effects of testosterone on the structural and contractile properties of the denervated rat skeletal muscles that were not influenced by neurotrophic-effects were investigated. Male Wistar strain rats (3-week-old, n=28) were used in the present study. All rats were divided into four (n=7, for each) groups ; control (C), testosterone control (TC), denervated (DN), and denervated with testosterone (DNT) groups. Sciatic nerves of DN and DNT groups' rats were resected at the 4-week-old after birth. Testosterone that was melted in corn-oil was administered (40 mg/kg body weight/week) for the TC and DNT groups. At the end of breeding period (15-week-old), soleus (SOL) and extensor digitorum longus (EDL) muscles were dissected from both hindlimbs and contractile profiles were analyzed in vitro. Relative weight (muscle weight/body weight) of SOL muscle in the DNT group was significantly (p<0.01) higher than that of the DN group. There is no significant difference in EDL muscle between the DN and DNT groups. Time to peak tension and half relaxation time in EDL muscle of the DNT group was significantly (p<0.05) higher than those of the DN group. Maximum twitch tension was prone to decrease following denervation, and significantly (p<0.01) difference between the DN and DNT groups in both muscles regarding the maximum twitch tension was observed. There is no significant difference of myosin and actomyosin ATPase activities comparison of each group in SOL muscle, however, the TC group were significantly higher than those of the C group in EDL muscle. These results suggested that the effects of testosterone for the hypertrophy in skeletal muscles were not synergistic effects with the neurotrophic-effects, however, for the ATPase in fast muscle act synergistically with the neurotrophic effect to change of myosin ATPase. Moreover, it was also suggested that the sensitivity to the  testosterone was different in each type of fiber. (Jpn. J. Phys. Fitness Sports Med. 1991, 40 : 41～47)},
 pages = {41--47},
 title = {除神経ラット骨格筋の収縮特性に及ぼすテストステロン投与の影響},
 volume = {40},
 year = {1991}
}