{"created":"2023-06-20T14:20:52.309442+00:00","id":626,"links":{},"metadata":{"_buckets":{"deposit":"7ceab459-4cb1-4bbc-8341-18cf92fd7f0a"},"_deposit":{"created_by":3,"id":"626","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"626"},"status":"published"},"_oai":{"id":"oai:aue.repo.nii.ac.jp:00000626","sets":["6:74:80"]},"author_link":["144"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Dopamine D1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex"}]},"item_3_biblio_info_7":{"attribute_name":"書誌事項","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"69","bibliographicPageStart":"63","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"愛知教育大学研究報告. 自然科学編"}]}]},"item_3_description_27":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dopamine is known to play roles in the processing of emotion. To test whether dopamine has effects on synaptic plasticity in emotion-processing areas, I examined callosally-evoked field potentials in coronal slices of rat anterior cingulate cortex （ACC） when low-frequency stimulation （LFS ）was applied to corpus callosum as a conditioning stimulus. Neither dopamine nor the D_2 agonist, quinpirole, had a significant effect on synaptic plasticity, while the D_1 agonist, SKF-38393, facilitated induction of long-term depression （LTD）. This facilitative effect of SKF-38393 was completely blocked by the D_1 antagonist, SCH-23390. LFS-induced LTD was not blocked by application of the metabotropic glutamatergic receptor antagonist, MCPG or the voltage-gated calcium channel blocker, nifedipine, but was blocked by application of the N-methyl-D-aspartate receptor （NMDAR） antagonist, APV. The facilitative effect of SKF-38393 on LTD induction was not mimicked by forskolin, an adenylcyclase activator, but was partially mimicked by phorbol 12, 13-didecanoate, which is known to activate the intracellular PKC pathway. These findings suggest that LTD in ACC is induced via NMDAR and facilitated by D_1 agonists at least in part via the PKC-related intracellular pathway. This type of facilitation of LTD induction may be related to the pathogenesis of schizophrenia or major depression, in which frontal lobe hypofunction has been indicated.","subitem_description_type":"Abstract"}]},"item_3_link_3":{"attribute_name":"研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Sakuragi, Sokichi","subitem_link_url":"https://souran.aichi-edu.ac.jp/teachers/ba8df83bfb620cc0.html"}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"愛知教育大学"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12466167","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-5169","subitem_source_identifier_type":"ISSN"}]},"item_3_text_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"subitem_text_value":"愛知教育大学研究報告, 自然科学編. 2011, 60, p. 63-69."}]},"item_3_text_26":{"attribute_name":"著者別名","attribute_value_mlt":[{"subitem_text_value":"サクラギ, ソウキチ"}]},"item_3_text_4":{"attribute_name":"著者(別言語)","attribute_value_mlt":[{"subitem_text_value":"桜木, 惣吉"}]},"item_3_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakuragi, Sokichi"}],"nameIdentifiers":[{"nameIdentifier":"144","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40225850","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40225850"},{"nameIdentifier":"40225850","nameIdentifierScheme":"KAKEN - 研究者検索","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000040225850/"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-27"}],"displaytype":"detail","filename":"kenshi606369.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kenshi606369.pdf","url":"https://aue.repo.nii.ac.jp/record/626/files/kenshi606369.pdf"},"version_id":"e51faed5-5347-40cf-9502-7cb0bb60449e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dopamine","subitem_subject_scheme":"Other"},{"subitem_subject":"D_1 agonist","subitem_subject_scheme":"Other"},{"subitem_subject":"low-frequency stimulation","subitem_subject_scheme":"Other"},{"subitem_subject":"LTD","subitem_subject_scheme":"Other"},{"subitem_subject":"anterior cingulate cortex","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-04-21"},"publish_date":"2011-04-21","publish_status":"0","recid":"626","relation_version_is_last":true,"title":["Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T15:59:23.618340+00:00"}