@article{oai:aue.repo.nii.ac.jp:00008257,
 author = {Habuchi, Osami},
 journal = {愛知教育大学研究報告. 自然科学編},
 month = {Mar},
 note = {text, Chondroitin sulfate is a group of polysaccharides containing repeating disaccharide units composed of GlcA-GalNAc. Each disaccharide unit bears sulfate groups on the various position of the component sugars: position 4 of GalNAc residues in A unit; position 6 of GalNAc residues in C unit; position 6 of GalNAc residue and position 2 of GlcA residue in D unit; and position 4 and 6 of GalNAc residue in E unit. Specific sulfotransferases are involved in the synthesis of these sulfate groups. Of these sulfotransferases, GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) and uronyl 2-O-sulfotransferase (2OST) are responsible for the formation of E unit and D unit, respectively. Both GalNAc4S-6ST and 2OST recognize not only the kind and position of the sugar residues but also sulfation pattern around the targeted sugar residues. GalNAc4S-6ST efficiently transfers sulfate to position 6 of GalNAc(4-SO_4) residue in a nonreducing terminal sequence, GalNAc(4-SO_4)-GlcA(2-SO_4)-GalNAc(6-SO_4) in addition to position 6 of GalNAc(4-SO_4) residue in the repeating disaccharides units. On the other hand, 2OST preferentially transfers sulfate to position 2 of GlcA residue in a sequence, GalNAc(4-SO_4)-GlcA-GalNAc(6-SO_4). A highly sulfated nonreducing terminal sequence, GalNAc(4, 6-SO_4)-GlcA(2-SO_4)-GalNAc(6-SO_4) appears to be produced by the concerted action of these sulfotransferases.},
 pages = {90--99},
 title = {Formation of a Highly Sulfated Nonreducing Terminal Sequence in Chondroitin Sulfate by Concerted Reactions of GalNAc 4-Sulfate 6-O-Sufotransferase and Uronyl 2-O-Sulfotransferase},
 volume = {71},
 year = {2022}
}