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チオレチナコ、オゾン、酸素を含む酸化的リン酸化の活性中心モデル
http://hdl.handle.net/10424/0002000583
http://hdl.handle.net/10424/00020005837560c117-3a70-4b05-b725-0a14361b476b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kenshi744754.pdf (979.4 KB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
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| 公開日 | 2025-03-26 | |||||||
| タイトル | ||||||||
| タイトル | チオレチナコ、オゾン、酸素を含む酸化的リン酸化の活性中心モデル | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | A Model for Oxidative Phosphorylation Active Site Including Thioretinaco, Ozone and Oxygen | |||||||
| 言語 | en | |||||||
| 著者 |
羽渕, 脩躬
× 羽渕, 脩躬
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| 著者(別言語) | ||||||||
| HABUCHI, Osami | ||||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | According to the studies of homocystinuria caused by different genetic defects, McCully concluded that homocysteine damages the artery by a direct effect on the arterial cells and tissues of children of homocystinuria. During the study using the cystathionine- β- synthetase deficient cells cultured from patients of homocystinuria, he found that sulfur atom of homocysteine thiolactone（HcyT）was converted to sulfate of proteoglycans. Since this mutant cell defects the pathway, HcyT→cystathionine→cysteine→sulfate, HcyT should be oxidized to sulfate through a different pathway. The growth of cells cultured from patients with homocystinuria showed abnormal contact inhibition, which is similar to that of cultured malignant cells. Because the growth pattern of cultured malignant cells is similar to the cultured cells from patients of homocystinuria, the metabolism of HcyT was studied in malignant cells. Normal cultured cells readily converted the sulfur atom of HcyT to sulfate esters of proteoglycans, but cultured malignant cells could not perform this oxidation process, but accumulate homocysteine thiolactone, which thiolates the free amino groups of cellular constituents. Aerobic glycolysis, the production of lactate from glucose in the presence of oxygen, has been known to be a characteristic pattern of oxidative metabolism in malignant cells. To explain the abnormality of HcyT metabolism and oxidative metabolism, a derivative of HcyT was supposed to present in normal cells but not in malignant cells. The chemical nature of this hypothetical substance was investigated by organic synthesis of a series of novel derivatives of HcyT and assay of these derivatives for anticarcinogenic activity. Thioretimamide （TR）, an amide of HcyT and retinoic acid, and thioretinaco（TR2Co）, a complex of TR and cobalamin, were found to have strong anticarcinogenic activity. From these results, McCully considered that deplete of TR2Co or its derivatives caused defect in oxidative phosphorylation in malignant cells. From the stereochemistry, McCully proposed that an active site of oxidative phosphorylation, which is composed of disulfonium complex between ozone, oxygen, TR2Co and ATP, is present in mitochondria, and that loss of this active site complex from mitochondria results in cancer and degenerative diseases associated with aging. | |||||||
| 言語 | en | |||||||
| bibliographic_information |
ja : 愛知教育大学研究報告. 自然科学編 巻 74, p. 47-54, 発行日 2025-03-01 |
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| 出版者 | ||||||||
| 出版者 | 愛知教育大学 | |||||||
| 言語 | ja | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1884-5169 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12466167 | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 著者別名 | ||||||||
| ハブチ, オサミ | ||||||||
| item_3_description_27 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | text | |||||||
| 言語 | en | |||||||
