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Upregulation of osteogenic factors induced by high-impact jumping suppresses adipogenesis in marrow but not adipogenic transcription factors in rat tibiae
http://hdl.handle.net/10424/3331
http://hdl.handle.net/10424/3331c9ffc642-1dd4-438b-af9d-24a2b1e1c168
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Kasugan001.pdf (349.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-06 | |||||
| タイトル | ||||||
| タイトル | Upregulation of osteogenic factors induced by high-impact jumping suppresses adipogenesis in marrow but not adipogenic transcription factors in rat tibiae | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Jump training | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mechanical loading | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pluripotent stem cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteoblast | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Adipocyte | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yuki, Atsumu
× Yuki, Atsumu× Yotani, Kengo× Tamaki, Hiroyuki× Kasuga, Norikatsu× Takekura, Hiroaki |
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| 研究者総覧へのリンク | ||||||
| 表示名 | Kasuga, Norikatsu | |||||
| URL | http://souran.aichi-edu.ac.jp/souran/profile.do?id=42JOT20W&lng=ja | |||||
| 著者(別言語) | ||||||
| 値 | 春日, 規克 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Jump training is a high-impact training regimen that increases bone volume in young bones. The aim of our study was to determine whether downregulation of adipogenesis that is associated with upregulation of osteogenesis is detected after jump training in growing rat tibiae. Four week-old rats were jump-trained for 1, 2, or 4 weeks for 5 days/week, and the height of jumping progressively increased to 35 cm.We performed morphometry to directly quantitate changes in bone volume and marrow adipocyte distribution in tibiae after the jump training.We also examined changes in expression of osteogenic and adipogenic transcription factor proteins and mRNAs after the jump training. Four weeks of jump training induced an increase in trabecular bone volume, which was associated with recruitment of runt-related transcription factor 2-expressing cells, as well as a decrease in marrow fat volume. However, peroxisome proliferator-activated receptor (PPAR) γ2 protein and mRNA expression levels did not change following high-impact jump training. The mRNA expression levels of the adipocyte differentiation genes CCAAT/enhancer-binding proteins (C/EBP) α, C/EBPβ, and C/EBPδ also showed no change during the training period in jump-trained rats. We suggest that levels of osteogenic factors that were upregulated by mechanical loading from high-impact jumping suppress adipogenesis in marrow rather than adipogenic transcription factors. | |||||
| 書誌事項 |
European Journal of Applied Physiology 巻 109, 号 4, p. 641-650, 発行日 2010-07 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1439-6319 | |||||
| 書誌情報 | ||||||
| 値 | European Journal of Applied Physiology. 2010, 109(4), p. 641-650. | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11413391 | |||||
| 権利 | ||||||
| 権利情報 | Copyright: 2010 Springer Verlag | |||||
| 権利 | ||||||
| 権利情報 | http://www.springerlink.com/content/h2480n425kk1r7q7/ ; The original publication is avairable at springerlink.com. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.springerlink.com/content/h2480n425kk1r7q7/ | |||||
| 関連名称 | http://www.springerlink.com/content/h2480n425kk1r7q7/ | |||||
| 関係URI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1007/s00421-010-1383-0 | |||||
| 関連名称 | http://dx.doi.org/10.1007/s00421-010-1383-0 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1007/s00421-010-1383-0 | |||||
| 著者別名 | ||||||
| 値 | ユキ, アツム | |||||
| 著者別名 | ||||||
| 値 | ヨタニ, ケンゴ | |||||
| 著者別名 | ||||||
| 値 | タマキ, ヒロユキ | |||||
| 著者別名 | ||||||
| 値 | カスガ, ノリカツ | |||||
| 著者別名 | ||||||
| 値 | タケクラ, ヒロアキ | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
