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Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex
http://hdl.handle.net/10424/3788
http://hdl.handle.net/10424/3788fbee55de-edf3-4d9b-8ca4-5463651294f2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kenshi606369.pdf (1.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-04-21 | |||||
| タイトル | ||||||
| タイトル | Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dopamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | D_1 agonist | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | low-frequency stimulation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | LTD | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anterior cingulate cortex | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Dopamine D1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex | |||||
| 著者 |
Sakuragi, Sokichi
× Sakuragi, Sokichi |
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| 研究者総覧へのリンク | ||||||
| Sakuragi, Sokichi | ||||||
| https://souran.aichi-edu.ac.jp/teachers/ba8df83bfb620cc0.html | ||||||
| 著者(別言語) | ||||||
| 桜木, 惣吉 | ||||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dopamine is known to play roles in the processing of emotion. To test whether dopamine has effects on synaptic plasticity in emotion-processing areas, I examined callosally-evoked field potentials in coronal slices of rat anterior cingulate cortex （ACC） when low-frequency stimulation （LFS ）was applied to corpus callosum as a conditioning stimulus. Neither dopamine nor the D_2 agonist, quinpirole, had a significant effect on synaptic plasticity, while the D_1 agonist, SKF-38393, facilitated induction of long-term depression （LTD）. This facilitative effect of SKF-38393 was completely blocked by the D_1 antagonist, SCH-23390. LFS-induced LTD was not blocked by application of the metabotropic glutamatergic receptor antagonist, MCPG or the voltage-gated calcium channel blocker, nifedipine, but was blocked by application of the N-methyl-D-aspartate receptor （NMDAR） antagonist, APV. The facilitative effect of SKF-38393 on LTD induction was not mimicked by forskolin, an adenylcyclase activator, but was partially mimicked by phorbol 12, 13-didecanoate, which is known to activate the intracellular PKC pathway. These findings suggest that LTD in ACC is induced via NMDAR and facilitated by D_1 agonists at least in part via the PKC-related intracellular pathway. This type of facilitation of LTD induction may be related to the pathogenesis of schizophrenia or major depression, in which frontal lobe hypofunction has been indicated. | |||||
| 書誌事項 |
愛知教育大学研究報告. 自然科学編 巻 60, p. 63-69, 発行日 2011-03-01 |
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| 出版者 | ||||||
| 出版者 | 愛知教育大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1884-5169 | |||||
| 書誌情報 | ||||||
| 愛知教育大学研究報告, 自然科学編. 2011, 60, p. 63-69. | ||||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12466167 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 著者別名 | ||||||
| サクラギ, ソウキチ | ||||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
