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Formation of a Highly Sulfated Nonreducing Terminal Sequence in Chondroitin Sulfate by Concerted Reactions of GalNAc 4-Sulfate 6-O-Sufotransferase and Uronyl 2-O-Sulfotransferase
http://hdl.handle.net/10424/00009390
http://hdl.handle.net/10424/00009390f1d2da62-9d56-4e82-9662-7dfd79138c45
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kenshi719099.pdf (797.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-29 | |||||
| タイトル | ||||||
| タイトル | Formation of a Highly Sulfated Nonreducing Terminal Sequence in Chondroitin Sulfate by Concerted Reactions of GalNAc 4-Sulfate 6-O-Sufotransferase and Uronyl 2-O-Sulfotransferase | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Habuchi, Osami
× Habuchi, Osami |
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| 著者(別言語) | ||||||
| 羽渕, 脩躬 | ||||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chondroitin sulfate is a group of polysaccharides containing repeating disaccharide units composed of GlcA-GalNAc. Each disaccharide unit bears sulfate groups on the various position of the component sugars: position 4 of GalNAc residues in A unit; position 6 of GalNAc residues in C unit; position 6 of GalNAc residue and position 2 of GlcA residue in D unit; and position 4 and 6 of GalNAc residue in E unit. Specific sulfotransferases are involved in the synthesis of these sulfate groups. Of these sulfotransferases, GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) and uronyl 2-O-sulfotransferase (2OST) are responsible for the formation of E unit and D unit, respectively. Both GalNAc4S-6ST and 2OST recognize not only the kind and position of the sugar residues but also sulfation pattern around the targeted sugar residues. GalNAc4S-6ST efficiently transfers sulfate to position 6 of GalNAc(4-SO_4) residue in a nonreducing terminal sequence, GalNAc(4-SO_4)-GlcA(2-SO_4)-GalNAc(6-SO_4) in addition to position 6 of GalNAc(4-SO_4) residue in the repeating disaccharides units. On the other hand, 2OST preferentially transfers sulfate to position 2 of GlcA residue in a sequence, GalNAc(4-SO_4)-GlcA-GalNAc(6-SO_4). A highly sulfated nonreducing terminal sequence, GalNAc(4, 6-SO_4)-GlcA(2-SO_4)-GalNAc(6-SO_4) appears to be produced by the concerted action of these sulfotransferases. | |||||
| 書誌事項 |
愛知教育大学研究報告. 自然科学編 巻 71, p. 90-99, 発行日 2022-03-01 |
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| 出版者 | ||||||
| 出版者 | 愛知教育大学 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1884-5169 | |||||
| 書誌情報 | ||||||
| 愛知教育大学研究報告, 自然科学編. 2022, 71, p. 90-99. | ||||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12466167 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 著者別名 | ||||||
| 科研費研究者番号,90024067 | ||||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
